Discovery蚂蚁淘在线

商品

品牌

文章

热门搜索：

快报

蚂蚁淘特色产品FLOWTECH造影剂蚂蚁淘授权代理品牌-德国Emfret 蚂蚁淘旗下188精品现货平台正式上线啦！！！蚂蚁淘四月促销蚂蚁淘获得vitanavitech代理商授权蚂蚁淘获得QA-bio代理商授权蚂蚁淘获得Viagenbiotech代理商授权 polysciences公司24765-1到现货了(内附代理商整理说明书）蚂蚁淘四月团建“环苏州古城一周” Clodronate Liposomes用量更正！

品牌首页品牌新闻品牌简介产品中心品牌咨询联系我们

品牌咨询

联系方式

公司地址

苏州工业园区生物纳米园A4#216

联系电话

4000-520-616 / 18915418616

传真号码

0512-67156496

电子邮箱

info@ebiomall.com

公司网址

https://www.ebiomall.com

蚂蚁淘在线 / 品牌中心 / Discovery / Discovery Antibodies/FPL 64176/10 mg/F-160-10 mg

Discovery Antibodies/FPL 64176/10 mg/F-160-10 mg

价格

￥1340.00

货号：F-160-10mg

浏览量：102

品牌：Discovery

服务

全国联保

正品保证

正规发票

签订合同

加入收藏

立即购买

商品描述

Cat#:F-160

LyophilizedPowder

BioassayTested

SourceSynthetic

MW:347.4

Purity:>99%(HPLC)

FormLyophilizedpowder.

Effectiveconcentration10nM-1µM.

Structure-+

Chemicalnamemethyl4-(2-benzylbenzoyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate.

MolecularformulaC₂₂H₂₁NO₃.

CASNo.:120934-96-5.

PubChemCID3423

ActivityFPL64176isanL-typeCa²⁺channelactivator,whichinducescontractioninrattailartery¹.

References-Activity-+

ShippingandstorageShippedatroomtemperature.Productassuppliedcanbestoredintactatroomtemperatureforseveralweeks.Forlongerperiods,itshouldbestoredat-20°C.

Solubility100mMinDMSO.Centrifugeallproductpreparationsbeforeuse(10000xgfor1min).

StorageofsolutionsUptofourweeksat4°Corthreemonthsat-20°C.

Ourbioassay-+

References-Scientificbackground

1.Zheng,W. etal. (1991) Mol.Pharmacol. 40, 734.

2.Ghais,N.S. etal. (2009) Exp.Physiol. 94, 240.

3.McDonough,S.I. etal. (2005) Biophys.J. 88, 211.

4.Fan,J.S. etal. (2002) Br.J.Pharmacol. 135, 1495.

5.Catterall,W.A. etal.(2003) Pharmacol.Rev. 55, 579.

Scientificbackground-+

TargetL-typeCa²⁺channels

LyophilizedPowder

Clickheretoreceivea5mgfreetrialsample!

Lastupdate:24/09/2019

FPL64176(#F-160)isahighlypure,synthetic,andbiologicallyactivecompound.

Forresearchpurposesonly,notforhumanuse

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。

资质认证

获得国家资质，权威认证！
全国联保

全国联保，官方无忧售后
正规发票

正规发票，放心购买
签订合同

签订合同，保障您的权益

/**/