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蚂蚁淘在线 / 品牌中心 / Discovery / Discovery Antibodies/CX 546/50 mg/C-210-50 mg

Discovery Antibodies/CX 546/50 mg/C-210-50 mg

价格

￥5540.00

货号：C-210-50mg

浏览量：103

品牌：Discovery

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商品描述

Cat#:C-210

LyophilizedPowder

BioassayTested

SourceSynthetic

MW:247.3

Purity:>99%

FormLyophilizedpowder.

Effectiveconcentration10-630µM.

Structure-+

Chemicalname(2,3-dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone.

MolecularformulaC₁₄H₁₇NO₃.

CASNo.:215923-54-9.

ActivityCX546isaselectiveAMPAreceptoragoNIST¹.

References-Activity-+

ShippingandstorageShippedatroomtemperature.Productassuppliedcanbestoredintactatroomtemperatureforseveralweeks.Forlongerperiods,itshouldbestoredat-20°C.

Solubility126mMinDMSO.Centrifugeallproductpreparationsbeforeuse(10000xgfor1min).

StorageofsolutionsUptofourweeksat4°Corthreemonthsat-20°C.

Ourbioassay-+

References-Scientificbackground

1.Arai,A.andLynch,G. (1998) BrainRes. 799, 235.

2.Arai,A.C.andKessler,M. (2007) Curr.DrugTargets 8, 583.

3.Nagarajan,N. etal. (2001) Neuropharmacology 41, 650.

Scientificbackground-+

TargetAMPAreceptors

LyophilizedPowder

Clickheretoreceivea5mgfreetrialsample!

Lastupdate:13/10/2019

CX546(#C-210) isahighlypure,synthetic,andbiologicallyactivecompound.

Forresearchpurposesonly,notforhumanuse

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。

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