Cataloguenumbercrb5005104AntibodyAnti-CTLA-4antibodyCRB4B8AntigenPeptideKLHconjugatedsyntheticpeptidecrb1200373eProteinIDUniProtKB-P16410AliasesCytotoxicT-lymphocyteprotein4,CD152(clusterofdifferentiation152Cross-ReactivityHumanHostSpeciesMouseAntibodyTypeMonoclonalConcentration1mg/mlValidationWB/ELISATargetsCTLA-4DiseaseAreaImmunehomeostasisSpecificitySolubleCTLA-4StorageThismaterialissuppliedinPBS,pH8containing1%trehalose.Theproductshouldbestoredat+4°Cforshorttermstorageand-80°Cforlongtermstorage.Avoidrepeatedfreeze/thawcycles.References

Esposito,L.,Hunter,K.,Clark,J.,Rainbow,D.,Stevens,H.,Denesha,J.,Duley,S.,Dawson,S.,Coleman,G.,Nutland,S.,Bell,G.,Moran,C.,Pekalski,M.,Todd,J.andWicker,L.(2014).InvestigationofSolubleandTransmembraneCTLA-4IsoformsinSerumandMicrovesicles.JImmunol,193(2),889-900.PMID:24928993

Sekiya,T.andTakaki,S.(2019).RGMBenhancesthesuppressiveactivityofthemonomericsecretedformofCTLA-4.SciRep,9(1).PMID:31061392

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。