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蚂蚁淘在线 / 品牌中心 / Discovery / Discovery Antibodies/Anti-Angiotensin II Receptor Type-2 (extracellular)-ATTO-488 Antibody/50 µl/AAR-012-AG-50 µl

Discovery Antibodies/Anti-Angiotensin II Receptor Type-2 (extracellular)-ATTO-488 Antibody/50 µl/AAR-012-AG-50 µl

价格

￥10540.00

货号：AAR-012-AG-50µl

浏览量：119

品牌：Discovery

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商品描述

Cat#:AAR-012-AG

AlternativeNameAT₂ Receptor,AT2R,AGTR2,MRX88

LyophilizedPowder

AntigenIncl.

Type:Polyclonal

Host:Rabbit

Reactivity:m,r

Immunogen-+

Accession(Uniprot)NumberP35351

GeneID24182

PeptideconfirmationConfirmedbyaminoacidanalysisandmassspectrometry.

HomologyMouse-identical.

RRIDAB_2039724.

PurityAffinitypurifiedonimmobilizedantigen.

FormLyophilizedpowder.Reconstitutedantibodycontainsphosphatebufferedsaline(PBS),pH7.4,1%BSA,0.05%NaN₃.

IsotypeRabbitIgG.

SpecificityWillnotrecognizehumanAT2Receptor.

LabelATTO-488.Maximumabsorption501nm;maximumfluorescence523nm.Thefluorescenceisexcitedmostefficientlyinthe480–515nmrange.Thislabelisanalogoustothewellknowndyefluoresceinisothiocyanate(FITC)andcanbeusedwithfilterstypicallyusedtodetectFITC.

StoragebeforereconstitutionTheantibodyshipsasalyophilizedpowderatroomtemperature.Uponarrival,itshouldbestoredat-20°C.

Reconstitution50µldoubledistilledwater(DDW).

Antibodyconcentrationafterreconstitution1mg/ml.

StorageafterreconstitutionThereconstitutedsolutioncanbestoredat4°C,protectedfromthelight,forupto1week.Forlongerperiods,smallaliquotsshouldbestoredat-20°C.Avoidmultiplefreezingandthawing.Centrifugeallantibodypreparationsbeforeuse(10000×g5min).

NegativecontrolantigenstoragebeforereconstitutionLyophilizedpowdercanbestoredintactatroomtemperaturefor2weeks.Forlongerperiods,itshouldbestoredat-20°C.

Negativecontrolantigenreconstitution100µldoubledistilledwater(DDW).

Negativecontrolantigenstorageafterreconstitution-20°C.

PreadsorptionControl1μgpeptideper1μgantibody.

StandardqualitycontrolofeachlotWesternblotanalysis(unlabeledantibody,#AAR-012),andimmunohistochemistry(labeledantibody).

Applications:ic,if,ih,lci

Immunohistochemistry-+

Livecellimaging/Immunocytochemistry-+

References

1.Mukoyama,M.etal.(1993)J.Biol.Chem.268,24539.

2.deGasparo,M.etal.(2000)Pharmacol.Rev.52,415.

3.Carey,R.M.andSiragy,H.M.(2003)Endocr.Rev.24,261.

Scientificbackground-+

LyophilizedPowderNegativeControlAntigenIncluded

Image&Title:

Immuno-colocalizationofMelatoninReceptorType1BandAT₂ ReceptorinratbrainImmunohistochemicalstainingofperfusion-fixedfrozenbrainsectionsusing Anti-MelatoninReceptor1B(MTNR1B)Antibody (#AMR-032),(1:600)and Anti-AngiotensinIIReceptorType-2(extracellular)-ATTO-488 Antibody(#AAR-012-AG),(1:100).A.MTNR1Bstaining(red)(arrows).B.ThesamesectionlabeledforAT₂receptor(green).C.Mergeofthetwoimagessuggestsconsiderableco-localizationintheparaventricularnucleus(arrows).Fororientation,notelocalizationwithrespectto3^rd ventricle(3^rd V).

Lastupdate:10/11/2019

Anti-AngiotensinIIReceptorType-2(extracellular)Antibody (#AAR-012)isahighlyspecificantibodydirectedagainstanextracellularepitopeoftheratprotein.The antibodycanbeusedinwesternblot,immunocytochemistryandimmunohistochemistryapplications.IthasbeendesignedtorecognizeAT₂receptorfromratandmousesamples.Theantibodywon’trecognizehumanAT2R.

Anti-AngiotensinIIReceptorType-2(extracellular)-ATTO-488Antibody(#AAR-012-AG)isdirectlylabeledwithanATTO-488fluorescentdye.ATTOdyesarecharacterizedbystrongabsorption(highextinctioncoefficient),highfluorescencequantumyield,andhighphoto-stABIlity.TheATTO-488labelisanalogoustothewellknowndyefluoresceinisothiocyanate(FITC)andcanbeusedwithfilterstypicallyusedtodetectFITC.Anti-AngiotensinIIReceptorType-2(extracellular)-ATTO-488AntibodyhasbeentestedinlivecellimagingandimmunohistochemicalapplicationsandisspeciallysuitedtoexperimentsrequiringsimultaneouslabelingofdifferentMarkers.

Forresearchpurposesonly,notforhumanuse

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。

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Discovery Antibodies/Anti-Angiotensin II Receptor Type-2 (extracellular)-ATTO-488 Antibody/50 µl/AAR-012-AG-50 µl

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