Catalogue numbercrb2005113AntibodyAnti-SLC15A4 AntibodyAntigen PeptideKLH conjugated synthetic peptide crb1200375eProtein IDUniProtKB - Q8N697AliasesSolute carrier family 15 member 4, Peptide transporter 4, Peptide/histidine transporter 1, hPHT1Cross-ReactivityHumanHost Species Anti-RabbitAntibody TypePolyclonalConcentration0.2mg/mlValidation1:1000 (WB), 1:1000 (ELISA)TargetSLC15A4 Disease AreaProton oligopeptide cotransporterFamily PTR2/POT transporter familySpecificityProtein Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.References

Griffith, A., Zaidi, A., Pietro, A., Hadiono, M., Yang, J., Davis, R. and Popkin, D. (2018). A requirement for slc15a4 in imiquimod-induced systemic inflammation and psoriasiform inflammation in mice. Sci Rep, 8(1). PMID: 30262916

Kobayashi, T., Tsutsui, H., Shimabukuro-Demoto, S., Yoshida-Sugitani, R., Karyu, H., Furuyama-Tanaka, K., Ohshima, D., Kato, N., Okamura, T. and Toyama-Sorimachi, N. (2017). Lysosome biogenesis regulated by the amino-acid transporter SLC15A4 is critical for functional integrity of mast cells. Int Immunol, 29(12), 551-566. PMID: 29155995

Yamashita, T., Shimada, S., Guo, W., Sato, K., Kohmura, E., Hayakawa, T., Takagi, T. and Tohyama, M. (1997). Cloning and Functional Expression of a Brain Peptide/Histidine Transporter. J Biol Chem, 272(15), 10205-10211. PMID: 9092568

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。