Catalogue numbercrb2005079AntibodyAnti-NeuN antibodyAntigen PeptideKLH conjugated synthetic peptide crb1200308eProtein IDSwissProt - A6NFN3AliasesRNA Binding Protein Fox-1 Homolog 3, Hexaribonucleotide Binding Protein 3, Neuronal Nuclei Antigen, Fox-1 Homolog C Cross-ReactivityHuman, Rat, MouseHost Species RabbitAntibody TypePolyclonalConcentration1mg/mlValidation1:1000 (ELISA), 1:1000 (IHC)TargetNeuNDisease AreaNeurodegenerativeFamilyFox-1Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles. References

V. V. Gusel’nikova and D. E. Korzhevskiy. 2015. NeuN As a Neuronal Nuclear Antigen and Neuron Differentiation Marker. Acta Naturae. 7(2): 42–47. PMID: 26085943

Yun Kyung Hahn, Ruturaj R. Masvekar, Ruqiang Xu, Kurt F. Hauser, and Pamela E. Knapp. 2015. Chronic HIV-1 Tat and HIV Reduce Rbfox3/NeuN: Evidence for Sex-Related Effects. Curr HIV Res; 13(1): 10–20. PMID: 25760045

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。