Catalogue number	crb2115007e
Antibody	Alexa Fluor® 488 Anti-mGluR2 Antibody
Antigen Peptide	KLH conjugated synthetic peptide crb1200279e
Protein ID	UniProtKB - Q14416
Aliases	GRM2, GPRC1B, MGLUR2, GLUR2, mGlu2, glutamate metabotropic receptor 2, mGluR2
Cross-Reactivity	Rat, Mouse
Host Species	Anti-Rabbit
Antibody Type	Polyclonal
Label	Labelled with Alexa Fluor® 488 under optimal conditions. Ex: 495nm Em:519nm
Concentration	0.36mg/ml
Validation	ELISA
Target	mGluR2
Disease Area	Neurodegenerative diseases
Family	G-protein coupled receptor 3 family
Specificity	Protein
Storage	Supplied in PBS containing 0.01% sodium azide. The product should be stored undiluted and protected from prolonged exposure to light. Short term storage between 2-8°C and long term storage below -20°C.
References	Meinhardt et al. (2013) J. Neurosci. 33 (7): 2794-2806. Nicholls et al. (2006) PNAS. 103 (16): 6380-6385

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。