Annotated and awaiting review. Please contact us if you can help with reviewing. BMP receptor IA|CD292|SKR5|activin receptor-like kinase 3|bone morphogenetic protein 4 receptor|BMP-2/BMP-4 receptor|ALK3|ACVRLK3|serine/threonine-protein kinase receptor R5|bone morphogenetic protein receptor Description: Crystal structure of a TGF-beta ligand-receptor complex between growth/differentiation factor 5 and bone morphogenetic protein receptor type-1A Download all structure-activity data for this target as a CSV file Clinically-Relevant Mutations and Pathophysiology Synonyms: Juvenile polyposis of infancy [Orphanet: ORPHA79076] Synonyms: Juvenile polypolis syndrome; JPS [OMIM: 174900] 1. Asai-Coakwell M, March L, Dai XH, Duval M, Lopez I, French CR, Famulski J, De Baere E, Francis PJ, Sundaresan P et al..(2013)Contribution of growth differentiation factor 6-dependent cell survival to early-onset retinal dystrophies. 2. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP.(2011)Comprehensive analysis of kinase inhibitor selectivity. 3. Engers DW, Frist AY, Lindsley CW, Hong CC, Hopkins CR.(2013)Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. 4. Mohedas AH, Wang Y, Sanvitale CE, Canning P, Choi S, Xing X, Bullock AN, Cuny GD, Yu PB.(2014)Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. 5. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al..(2010)Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Type I receptor serine/threonine kinases: bone morphogenetic protein receptor type IA. Last modified on 10/07/2018. Accessed on 18/05/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1786.

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