Melanoma Dextramer Collection 1

Product Code: RX01

Collection of 6 carefully selected melanoma specific MHC I Dextramers (+ 1 control), for sensitive and specific detection of antigen-specific T cells using flow cytometry. Delivery of two aliquots/antigen with different fluorescent labels (PE and APC). Amount: 14 x 25 testsApplication(s): Cellular immune response, Immune monitoring, T-cell assays, Determination of pre-existing and induced immunityIndication(s)/Topic(s): Cancer, Cancer chemotherapy, Control, Melanoma, VaccinationDelivery Time: 10-12 days

MHC I Dextramer Collections MHC class I Dextramers combine a dextran polymer backbone with a high number of MHC and fluorochrome molecules providing mulitple binding domains for antigen-specific T cell receptor binding. This enhances their staining intensity and increases resolution as well as signal-to-noise ratio with minimal background staining. In addition, the dextran backbone stabilizes the MHC-peptide complexes and fluorochromes. The Melanoma set is useful for enumeration of melanoma-specific CD8+ T cells, to detect or isolate melanoma-specific CD8+ T cells, e.g. during cancer vaccine and immunotherapeutic development. Each Dextramer is provided both as a PE- and APC conjugate, allowing for double staining of each cell sample to better resolve positive from negative cell populations. The following 7 Dextramers are provided each with APC and PE labelDextramer: HLA-A*0201 / ELAGIGILTV - Antigen: MART-1 Dextramer: HLA-A*0201 / SLLMWITQV - Antigen: NY-ESO-1Dextramer: HLA-A*0201 / KVAELVHFL - Antigen: MAGE-A3 Dextramer: HLA-A*0201 / YMDGTMSQV - Antigen: TyrosinaseDextramer: HLA-A*0201 / IMDQVPFSV - Antigen: gp100 Dextramer: HLA-A*0201 / KVLEYVIKV - Antigen: MAGE-A1 Dextramer: HLA-A*0201 / Negative Control

Benefits of MHC I Dextramer® Collections- More MHC molecules and more fluorochromes than conventional MHC multimers- Higher sensitivity (important for low-affinity epitopes as commonly found in cancer & autoimmune disease)- High stability- Custom-made Dextramer available upon request

Melanoma Dextramer Collection 1

Selected References for MHC I Dextramers®\"Combination Immunotherapy after ASCT for Multiple Myeloma Using MAGE-A3/Poly-ICLC Immunizations Followed by Adoptive Transfer of Vaccine-Primed and Costimulated Autologous T Cells\"Rapoport et al., Clin Cancer Res (2014) - PMID: 24520093 \"Molecular Imprint of Exposure to Naturally Occurring Genetic Variants of Human Cytomegalovirus on the T cell Repertoire\" Smith et al., Sci Rep (2014) - PMID: 24509977\"Probing the effector and suppressive functions of human T cell subsets using antigen-specific engineered T cell receptors\"Wan et al., PLoS One (2013) Full text \"Human Natural Killer Cells Prevent Infectious Mononucleosis Features by Targeting Lytic Epstein-Barr Virus Infection\" Chijioke et al., Cell Rep (2013) - PMID: 24360958

Melanoma Dextramer Collection 1

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