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关闭开始聊天Description: Highly potent H1 antagonist. Also binds to H4 receptor Chemical Name: 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin hydrochloride Purity: ≥99% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferencesBiological Activity
Highly potent H1 histamine receptor antagonist (Kd = 310 pM) and tricyclic antidepressant. Also binds to the H4 histamine receptor (pKi = 6.79).
Technical Data
| M. Wt | 315.84 |
| Formula | C19H21NO.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1229-29-4 |
| PubChem ID | 5281088 |
| InChI Key | MHNSPTUQQIYJOT-CULRIWENSA-N |
| Smiles | Cl[H].CN(C)CCC=C1C2=C(COC3=C1C=CC=C3)C=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| DMSO | 31.58 | 100 |
| water | 31.58 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 315.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 1 mM | 3.17 mL | 15.83 mL | 31.66 mL |
| 5 mM | 0.63 mL | 3.17 mL | 6.33 mL |
| 10 mM | 0.32 mL | 1.58 mL | 3.17 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.63 mL |
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Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDSReferences
References are publications that support the products\' biological activity.
Lurchins (1983) Review of clinical and animal studies comparing the cardiovascular effects of doxepin and other tricyclic antidepressants. Am.J.Psychiatry 140 1006 PMID: 6346907
Nguyen et al (2001) Discovery of a novel member of the histamine receptor family. Mol.Pharmacol. 59 427 PMID: 11179435
Tran et al (1981) [3H]Doxepin interactions with histamine H1-receptors and other sites in guinea pig brain homogenates. Eur.J.Pharmacol. 70 501 PMID: 7238574
Merck Index 12 3492 PMID:
Keywords: Doxepin hydrochloride, supplier, potent, H1, antagonists, binds, H4, Receptors, Histamine, histaminergic, Histamine, H1, Receptors, Histamine, H1, Receptors, Tocris Bioscience
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