Description: Standard H₃ and H₄ agonist (H₃ > H₄) Chemical Name: 5-[2-(Imidazol-4-yl)ethyl]isothiourea dihydrobromide Purity: ≥98% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

An extremely potent, high affinity agonist at H₃ and H₄ receptors (K_i values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC₅₀ of 25 nM. Centrally active following systemic administration. Also available as part of the Histamine H₃ Receptor Tocriset™.

Technical Data

M. Wt	332.06
Formula	C6H10N4S.2HBr
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	32385-58-3
PubChem ID	11957573
InChI Key	DOBOYMKCRRLTRF-UHFFFAOYSA-N
Smiles	Br.Br.NC(=N)SCCC1=CNC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

water	33.21	100

Preparing Stock Solutions

The following data is based on the product molecular weight 332.06. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	3.01 mL	15.06 mL	30.12 mL
5 mM	0.6 mL	3.01 mL	6.02 mL
10 mM	0.3 mL	1.51 mL	3.01 mL
50 mM	0.06 mL	0.3 mL	0.6 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Farzin and Attarzadeh (2000) Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rats. Eur.J.Pharmacol. 404 169 PMID: 10980276

Garbarg et al (1992) S-[2-(4-Imidazolyl)ethyl]isothiourea, a highly specific and potent histamine H₃ receptor agonist. J.Pharmacol.Exp.Ther. 263 304 PMID: 1383495

Ling et al (2004) Histamine H₄ receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation. Br.J.Pharmacol. 142 161 PMID: 15131002

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Keywords: Imetit dihydrobromide, supplier, H3, H4, agonists, Receptors, Histamine, histaminergic, Histamine, H3, Receptors, Histamine, H4, Receptors, Histamine, H3, Receptors, Tocris Bioscience

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