Description: A_2A agonist Chemical Name: 4-[2-[[6-Amino-9-(N-ethyl-β-D-ribofuranuronamidosyl)-9H-purin-2-yl]amino]ethyl]benzenepropanoic acid hydrochloride Purity: ≥98% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

A_2A adenosine receptor agonist (K_i = 27 nM). Has affinity for A₁ and A₃ adenosine receptors but can be used to distinguish A_2A- and A_2B-mediated effects.

Technical Data

M. Wt	535.99
Formula	C23H29N7O6.HCl
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	124431-80-7
PubChem ID	10256643
InChI Key	QPHVMNOEKKJYJO-MJWSIIAUSA-N
Smiles	NC1=NC(NCCC4=CC=C(CCC(O)=O)C=C4)=NC2=C1N=CN2[C@@H]3O[C@H]([C@](NCC)=O)[C@@H](O)[C@H]3O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

2.25eq. NaOH	53.6	100
DMSO	53.6	100

Preparing Stock Solutions

The following data is based on the product molecular weight 535.99. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	1.87 mL	9.33 mL	18.66 mL
5 mM	0.37 mL	1.87 mL	3.73 mL
10 mM	0.19 mL	0.93 mL	1.87 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Klot (2000) Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch.Pharmacol. 362 382 PMID: 11111832

Nekooeian and Tabrizchi (1998) Effects of CGS 21680, a selective A_2A adenosine receptor agonist, on cardiac output and vascular resistance in acute heart failure in the anaesthetized rat. Br.J.Pharmacol. 123 1666 PMID: 9605574

Phillis et al (1990) The selective adenosine A₂ receptor agonist, CGS 21680, is a potent depressant of cerebral cortical neuronal activity. Brain Res. 509 328 PMID: 2322828

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Keywords: CGS 21680 hydrochloride, supplier, A2A, agonists, Receptors, adenosines, CGS21680, hydrochloride, Adenosine, A2A, Receptors, Adenosine, A2A, Receptors, Tocris Bioscience

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