Description: Selective mGlu₄ agonist Chemical Name: 2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid Purity: ≥98% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

mGlu₄ receptor agonist. Activates mGlu₄ receptors in transiently transfected HEK293 cells; selective over all other mGlu subtypes (mGlu₁, mGlu₂ and mGlu_5-8). Decreases cAMP levels in native cultured cerebellar granule cells. Also counteracts excitotoxic neuronal cell death induced by NMDA in mixed cultures of cortical cells; displays neuroprotective activity.

Technical Data

M. Wt	300.22
Formula	C14H8N2O6
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	606-59-7
PubChem ID	114918
InChI Key	FSBKJYLVDRVPTK-UHFFFAOYSA-N
Smiles	O=C2C(N)=C(C(O)=O)C1=NC3=C(C=CC=C3C(O)=O)OC1=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

DMSO	30.02	100

Preparing Stock Solutions

The following data is based on the product molecular weight 300.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	3.33 mL	16.65 mL	33.31 mL
5 mM	0.67 mL	3.33 mL	6.66 mL
10 mM	0.33 mL	1.67 mL	3.33 mL
50 mM	0.07 mL	0.33 mL	0.67 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Fazio (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type-4 metabotropic glutamate receptors. Mol.Pharmacol. Feb 6 Epub ahead of print PMID: 22311707

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Keywords: Cinnabarinic acid, supplier, metabotropic, glutamate, mglu4, agonists, selective, Glutamate, (Metabotropic), Group, III, Receptors, Glutamate, (Metabotropic), Group, III, Receptors, Tocris Bioscience

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