Description: Potent and selective FFA4 (GPR120) agonist Chemical Name: 4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide Purity: ≥99% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Potent and selective FFA4 (GPR120) agonist (pEC₅₀ values are 6.3, 6.2 and 6.1 at the human, mouse and rat receptor, respectively). Exhibits ≥100-fold selectivity against a panel of 61 targets including FFA1, FFA2 and FFA3. Enhances glucose-stimulated insulin secretion in MIN6 cells. Induces intracellular calcium accumulation in U2OS cells; this activity is inhibited by AH 7614 (Cat. No. 5256).

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Compound Libraries

GSK 137647 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	305.39
Formula	C16H19NO3S
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	349085-82-1
PubChem ID	743974
InChI Key	FQUAFMNPXPXOJE-UHFFFAOYSA-N
Smiles	CC1=CC(C)=CC(C)=C1NS(C2=CC=C(OC)C=C2)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

DMSO	30.54	100
ethanol	15.27	50

Preparing Stock Solutions

The following data is based on the product molecular weight 305.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	3.27 mL	16.37 mL	32.75 mL
5 mM	0.65 mL	3.27 mL	6.55 mL
10 mM	0.33 mL	1.64 mL	3.27 mL
50 mM	0.07 mL	0.33 mL	0.65 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Sparks et al (2014) Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). Bioorg.Med.Chem.Lett. 24 3100 PMID: 24881566

Martin et al (2012) Lipid-mediated release of GLP-1 by mouse taste buds from circumvallate papillae: putative involvement of GPR120 and impact on taste sensitivity. J.Lipid Res. 53 2256 PMID: 22904345

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Keywords: GSK 137647, supplier, GSK137647, Free, fatty, acid, receptor, 4, diabetes, potent, and, selective, FFA4, GPR120, agonist, Free, Fatty, Acid, Receptors, Free, Fatty, Acid, Receptors, Tocris Bioscience

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