Description: Brain penetrant, selective GABA_B antagonist Chemical Name: (3-Aminopropyl)(cyclohexylmethyl)phosphinic acid Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Brain penetrant, selective GABA_B receptor antagonist (IC₅₀ = 4.9 μM).

Licensing Information

Sold with the permission of Novartis Pharma AG

Technical Data

M. Wt	219.26
Formula	C10H22NO2P
Storage	Store at RT
CAS Number	123691-14-5
PubChem ID	130022
InChI Key	XOESDNIUAWGCLU-UHFFFAOYSA-N
Smiles	NCCCP(CC1CCCCC1)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

water	21.93	100

Preparing Stock Solutions

The following data is based on the product molecular weight 219.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	4.56 mL	22.8 mL	45.61 mL
5 mM	0.91 mL	4.56 mL	9.12 mL
10 mM	0.46 mL	2.28 mL	4.56 mL
50 mM	0.09 mL	0.46 mL	0.91 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Curtis and Lacey (1998) Prolonged GABA_B receptor-mediated synaptic inhibition in the cat spinal cord: an in vivo study. Exp.Brain Res. 121 319 PMID: 9746138

Staubli et al (1999) GABA_B receptor antagonism: facilitatory effects on memory parallel those on LTP induced by TBS but not HFS. J.Neurosci. 19 4609 PMID: 10341258

Lingenhoehl and Olpe (1993) Blockade of the late inhibitory postsynaptic potential in vivo by the GABA_B antagonist CGP 46381. Pharmacol.Comm. 3 49 PMID:

Froestl et al (1996) Potent, orally active GABA_B receptor antagonists. Pharmacol.Rev.Comm. 8 127 PMID:

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Keywords: CGP 46381, supplier, Brain, penetrant, selective, GABAB, antagonist, Receptors, CGP46381, GABAB, Receptors, GABAB, Receptors, Tocris Bioscience

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