Description: Group III mGlu agonist Chemical Name: (1S,3R,4S)-1-Aminocyclopentane-1,3,4-tricarboxylic acid Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Agonist for group III mGlu receptors (EC₅₀ values are 7.2 and 8.2 μM for mGlu_4a and mGlu₈ respectively). Anticonvulsant in mice.

Licensing Information

Sold with the permission of the CNRS

Technical Data

M. Wt	217.18
Formula	C8H11NO6
Storage	Desiccate at -20°C
CAS Number	194918-76-8
PubChem ID	4302960
InChI Key	JARNORYOPMINDY-UHFFFAOYSA-N
Smiles	N[C@]1([C@](O)=O)C[C@@H]([C@](O)=O)[C@@H]([C@@](O)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

1.1eq. NaOH	10.86	50
water	2.17	10

Preparing Stock Solutions

The following data is based on the product molecular weight 217.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	4.6 mL	23.02 mL	46.04 mL
5 mM	0.92 mL	4.6 mL	9.21 mL
10 mM	0.46 mL	2.3 mL	4.6 mL
50 mM	0.09 mL	0.46 mL	0.92 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Acher et al (1997) Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. J.Med.Chem. 40 3119 PMID: 9301676

Chapman et al (2001) Anticonvulsant activity of a mGlu_4α receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid. Eur.J.Pharmacol. 424 107 PMID: 11476756

De Colle et al (2000) Pharmacological characterization of the rat metabotropic glutamate receptor 8a revealed strong similarities and slight differences with the type 4a receptor. Eur.J.Pharmacol. 394 17 PMID: 10771029

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Keywords: ACPT-I, supplier, Group, III, agonists, Receptors, mGlu4, mGlu6, mGlu7, mGlu8, mGluR4, mGluR6, mGluR7, mGluR8, Glutamate, Metabotropic, Glutamate, (Metabotropic), Group, III, Receptors, Glutamate, (Metabotropic), Group, III, Receptors, Tocris Bioscience

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