Description: Potent adenosine receptor antagonist Chemical Name: 9-Chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine Purity: ≥99% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Potent adenosine receptor antagonist (K_i values are 3.5, 4.2, 16 and 51 nM for human A₁, A_2A, A_2B and A₃ receptors respectively). Orally active in vivo.

Technical Data

M. Wt	285.69
Formula	C13H8ClN5O
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	104615-18-1
PubChem ID	122070
InChI Key	JLPYLHLUHJOPNL-UHFFFAOYSA-N
Smiles	NC1=NC2=CC=C(Cl)C=C2C2=NC(=NN12)C1=CC=CO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

DMSO	1.43	5

Preparing Stock Solutions

The following data is based on the product molecular weight 285.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	3.5 mL	17.5 mL	35 mL
5 mM	0.7 mL	3.5 mL	7 mL
10 mM	0.35 mL	1.75 mL	3.5 mL
50 mM	0.07 mL	0.35 mL	0.7 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Ghai et al (1987) Pharmacological characterization of CGS 15943A: a novel nonxanthine adenosine antagonist. J.Pharmacol.Exp.Ther. 242 784 PMID: 3656113

Klotz (2000) Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch.Pharmacol. 362 382 PMID: 11111832

Williams et al (1987) Biochemical characterization of the triazoloquinazoline CGS 15943, a novel, non-xanthine adenosine antagonist. J.Pharmacol.Exp.Ther. 241 415 PMID: 2883298

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Keywords: CGS 15943, supplier, Potent, adenosines, receptor, antagonists, Non-Selective, Receptors, CGS15943, Non-selective, Adenosine, Non-selective, Adenosine, Tocris Bioscience

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