Nam M, Han K, Lee J, Won W, Koh W, Bae J, et al. Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference. Cell Rep. 2019;28:1154-1166.e5 pubmed出版商 Birdsong W, Jongbloets B, Engeln K, Wang D, Scherrer G, Mao T. Synapse-specific opioid modulation of thalamo-cortico-striatal circuits. elife. 2019;8: pubmed出版商 Hui K, Takashima N, Watanabe A, Chater T, Matsukawa H, Nekooki Machida Y, et al. GABARAPs dysfunction by autophagy deficiency in adolescent brain impairs GABAA receptor trafficking and social behavior. Sci Adv. 2019;5:eaau8237 pubmed出版商 Brodnik Z, Batra A, Oleson E, Espana R. Local GABAA Receptor-Mediated Suppression of Dopamine Release within the Nucleus Accumbens. ACS Chem Neurosci. 2019;10:1978-1985 pubmed出版商 Meira T, Leroy F, Buss E, Oliva A, Park J, Siegelbaum S. A hippocampal circuit linking dorsal CA2 to ventral CA1 critical for social memory dynamics. Nat Commun. 2018;9:4163 pubmed出版商 Chang J, Higley M. Potassium channels contribute to activity-dependent regulation of dendritic inhibition. Physiol Rep. 2018;6:e13747 pubmed出版商 Morel C, Sherrin T, Kennedy N, Forest K, Avcioglu Barutcu S, Robles M, et al. JIP1-Mediated JNK Activation Negatively Regulates Synaptic Plasticity and Spatial Memory. J Neurosci. 2018;38:3708-3728 pubmed出版商 Namikawa M, Sano A, Tateno T. Salicylate-Induced Suppression of Electrically Driven Activity in Brain Slices from the Auditory Cortex of Aging Mice. Front Aging Neurosci. 2017;9:395 pubmed出版商 Leroy F, Brann D, Meira T, Siegelbaum S. Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory. Neuron. 2017;95:1089-1102.e5 pubmed出版商 Hashimotodani Y, Nasrallah K, Jensen K, Chavez A, Carrera D, Castillo P. LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance. Neuron. 2017;95:928-943.e3 pubmed出版商 Sun Q, Sotayo A, Cazzulino A, Snyder A, Denny C, Siegelbaum S. Proximodistal Heterogeneity of Hippocampal CA3 Pyramidal Neuron Intrinsic Properties, Connectivity, and Reactivation during Memory Recall. Neuron. 2017;95:656-672.e3 pubmed出版商 Boehringer R, Polygalov D, Huang A, Middleton S, Robert V, Wintzer M, et al. Chronic Loss of CA2 Transmission Leads to Hippocampal Hyperexcitability. Neuron. 2017;94:642-655.e9 pubmed出版商 Hirono M, Nagao S, Yanagawa Y, Konishi S. Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells. Neuropharmacology. 2017;118:79-89 pubmed出版商 Mamaligas A, Cai Y, Ford C. Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission. Sci Rep. 2016;6:37834 pubmed出版商 Kim K, Ramiro Diaz J, Iddings J, Filosa J. Vasculo-Neuronal Coupling: Retrograde Vascular Communication to Brain Neurons. J Neurosci. 2016;36:12624-12639 pubmed Di Castro M, Trettel F, Milior G, Maggi L, Ragozzino D, Limatola C. The chemokine CXCL16 modulates neurotransmitter release in hippocampal CA1 area. Sci Rep. 2016;6:34633 pubmed出版商 Selten M, Meyer F, Ba W, Vallès A, Maas D, Negwer M, et al. Increased GABAB receptor signaling in a rat model for schizophrenia. Sci Rep. 2016;6:34240 pubmed出版商 Philippart F, Destreel G, Merino Sepúlveda P, Henny P, Engel D, Seutin V. Differential Somatic Ca2+ Channel Profile in Midbrain Dopaminergic Neurons. J Neurosci. 2016;36:7234-45 pubmed出版商 Colavita M, Terral G, Lemercier C, Drago F, Marsicano G, Massa F. Layer-specific potentiation of network GABAergic inhibition in the CA1 area of the hippocampus. Sci Rep. 2016;6:28454 pubmed出版商 Wozniak M, Acher F, Marciniak M, Lasoń Tyburkiewicz M, Gruca P, Papp M, et al. Involvement of GABAB Receptor Signaling in Antipsychotic-like Action of the Novel Orthosteric Agonist of the mGlu4 Receptor, LSP4-2022. Curr Neuropharmacol. 2016;14:413-26 pubmed Delaney A, Crane J. Presynaptic GABAB receptors reduce transmission at parabrachial synapses in the lateral central amygdala by inhibiting N-type calcium channels. Sci Rep. 2016;6:19255 pubmed出版商 Dennis S, Pasqui F, Colvin E, Sanger H, Mogg A, Felder C, et al. Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus. Cereb Cortex. 2016;26:414-26 pubmed出版商 Wang K, Kelley M, Wu W, Adelman J, Maylie J. Apamin Boosting of Synaptic Potentials in CaV2.3 R-Type Ca2+ Channel Null Mice. PLoS ONE. 2015;10:e0139332 pubmed出版商 Gantz S, Robinson B, Buck D, Bunzow J, Neve R, Williams J, et al. Distinct regulation of dopamine D2S and D2L autoreceptor signaling by calcium. elife. 2015;4: pubmed出版商 Tabatadze N, Huang G, May R, Jain A, Woolley C. Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus. J Neurosci. 2015;35:11252-65 pubmed出版商 Piccart E, Courtney N, Branch S, Ford C, Beckstead M. Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons. J Neurosci. 2015;35:11144-52 pubmed出版商 Abdi A, Mallet N, Mohamed F, Sharott A, Dodson P, Nakamura K, et al. Prototypic and arkypallidal neurons in the dopamine-intact external globus pallidus. J Neurosci. 2015;35:6667-88 pubmed出版商 Owen B, Grover L. Activity-dependent differences in function between proximal and distal Schaffer collaterals. J Neurophysiol. 2015;113:3646-62 pubmed出版商 Bajo M, Varodayan F, Madamba S, Robert A, Casal L, Oleata C, et al. IL-1 interacts with ethanol effects on GABAergic transmission in the mouse central amygdala. Front Pharmacol. 2015;6:49 pubmed出版商 Yang Y, Hu C, Lai Y. Non-additive modulation of synaptic transmission by serotonin, adenosine, and cholinergic modulators in the sensory thalamus. Front Cell Neurosci. 2015;9:60 pubmed出版商 Dilger E, Krahe T, Morhardt D, Seabrook T, Shin H, Guido W. Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement. J Neurosci. 2015;35:3652-62 pubmed出版商 Qi Y, Klyubin I, Harney S, Hu N, Cullen W, Grant M, et al. Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human A????-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: rapid reversal by anti-A???? agents. Acta Neuropathol Commun. 2014;2:175 pubmed出版商 Marcott P, Mamaligas A, Ford C. Phasic dopamine release drives rapid activation of striatal D2-receptors. Neuron. 2014;84:164-176 pubmed出版商 Stratton M, Staros M, Büdefeld T, Searcy B, Nash C, Eitel C, et al. Embryonic GABA(B) receptor blockade alters cell migration, adult hypothalamic structure, and anxiety- and depression-like behaviors sex specifically in mice. PLoS ONE. 2014;9:e106015 pubmed出版商 Wang X, Cheng Z, Schmid K. GABAB receptors expressed in human aortic endothelial cells mediate intracellular calcium concentration regulation and endothelial nitric oxide synthase translocation. Biomed Res Int. 2014;2014:871735 pubmed出版商 Medrihan L, Ferrea E, Greco B, Baldelli P, Benfenati F. Asynchronous GABA Release Is a Key Determinant of Tonic Inhibition and Controls Neuronal Excitability: A Study in the Synapsin II-/- Mouse. Cereb Cortex. 2015;25:3356-68 pubmed出版商 Kramer F, Griesemer D, Bakker D, Brill S, Franke J, Frotscher E, et al. Inhibitory glycinergic neurotransmission in the mammalian auditory brainstem upon prolonged stimulation: short-term plasticity and synaptic reliability. Front Neural Circuits. 2014;8:14 pubmed出版商 Muralidhar S, Wang Y, Markram H. Synaptic and cellular organization of layer 1 of the developing rat somatosensory cortex. Front Neuroanat. 2013;7:52 pubmed出版商 Kallupi M, Varodayan F, Oleata C, Correia D, Luu G, Roberto M. Nociceptin/orphanin FQ decreases glutamate transmission and blocks ethanol-induced effects in the central amygdala of naive and ethanol-dependent rats. Neuropsychopharmacology. 2014;39:1081-92 pubmed出版商 Wu W, Bryant D, Dorsa D, Adelman J, Maylie J. Ovarian hormone loss impairs excitatory synaptic transmission at hippocampal CA3-CA1 synapses. J Neurosci. 2013;33:16158-69 pubmed出版商 Razik D, Hawellek D, Antkowiak B, Hentschke H. Impairment of GABA transporter GAT-1 terminates cortical recurrent network activity via enhanced phasic inhibition. Front Neural Circuits. 2013;7:141 pubmed出版商 Toader O, Forte N, Orlando M, Ferrea E, Raimondi A, Baldelli P, et al. Dentate gyrus network dysfunctions precede the symptomatic phase in a genetic mouse model of seizures. Front Cell Neurosci. 2013;7:138 pubmed出版商 Hayama T, Noguchi J, Watanabe S, Takahashi N, Hayashi Takagi A, Ellis Davies G, et al. GABA promotes the competitive selection of dendritic spines by controlling local Ca2+ signaling. Nat Neurosci. 2013;16:1409-16 pubmed出版商 Araragi N, Mlinar B, Baccini G, Gutknecht L, Lesch K, Corradetti R. Conservation of 5-HT1A receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis. Front Pharmacol. 2013;4:97 pubmed出版商 Medrihan L, Cesca F, Raimondi A, Lignani G, Baldelli P, Benfenati F. Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels. Nat Commun. 2013;4:1512 pubmed出版商 Einstein E, Asaka Y, Yeckel M, Higley M, Picciotto M. Galanin-induced decreases in nucleus accumbens/striatum excitatory postsynaptic potentials and morphine conditioned place preference require both galanin receptor 1 and galanin receptor 2. Eur J Neurosci. 2013;37:1541-9 pubmed出版商 Lee C, Machold R, Witkovsky P, Rice M. TRPM2 channels are required for NMDA-induced burst firing and contribute to H(2)O(2)-dependent modulation in substantia nigra pars reticulata GABAergic neurons. J Neurosci. 2013;33:1157-68 pubmed出版商 Jurgens C, Bell K, McQuiston A, Guido W. Optogenetic stimulation of the corticothalamic pathway affects relay cells and GABAergic neurons differently in the mouse visual thalamus. PLoS ONE. 2012;7:e45717 pubmed出版商 Cruz M, Herman M, Cote D, Ryabinin A, Roberto M. Ghrelin increases GABAergic transmission and interacts with ethanol actions in the rat central nucleus of the amygdala. Neuropsychopharmacology. 2013;38:364-75 pubmed出版商 Lemos J, Roth C, Messinger D, Gill H, Phillips P, Chavkin C. Repeated stress dysregulates ?-opioid receptor signaling in the dorsal raphe through a p38? MAPK-dependent mechanism. J Neurosci. 2012;32:12325-36 pubmed出版商 Zhu Y, Dua S, Gold M. Inflammation-induced shift in spinal GABA(A) signaling is associated with a tyrosine kinase-dependent increase in GABA(A) current density in nociceptive afferents. J Neurophysiol. 2012;108:2581-93 pubmed出版商 Pennock R, Dicken M, Hentges S. Multiple inhibitory G-protein-coupled receptors resist acute desensitization in the presynaptic but not postsynaptic compartments of neurons. J Neurosci. 2012;32:10192-200 pubmed出版商 Zhu Y, Lu S, Gold M. Persistent inflammation increases GABA-induced depolarization of rat cutaneous dorsal root ganglion neurons in vitro. Neuroscience. 2012;220:330-40 pubmed出版商 Hulme S, Jones O, Ireland D, Abraham W. Calcium-dependent but action potential-independent BCM-like metaplasticity in the hippocampus. J Neurosci. 2012;32:6785-94 pubmed出版商 Ilie A, Raimondo J, Akerman C. Adenosine release during seizures attenuates GABAA receptor-mediated depolarization. J Neurosci. 2012;32:5321-32 pubmed出版商 Navarrete M, Perea G, Fernandez de Sevilla D, Gomez Gonzalo M, Nunez A, Martin E, et al. Astrocytes mediate in vivo cholinergic-induced synaptic plasticity. PLoS Biol. 2012;10:e1001259 pubmed出版商 Engbers J, Anderson D, Asmara H, Rehak R, Mehaffey W, Hameed S, et al. Intermediate conductance calcium-activated potassium channels modulate summation of parallel fiber input in cerebellar Purkinje cells. Proc Natl Acad Sci U S A. 2012;109:2601-6 pubmed出版商 He S, Shao L, Rittase W, Bausch S. Increased Kv1 channel expression may contribute to decreased sIPSC frequency following chronic inhibition of NR2B-containing NMDAR. Neuropsychopharmacology. 2012;37:1338-56 pubmed出版商 Zhu P, Huang W, Kalikulov D, Yoo J, Placzek A, Stoica L, et al. Suppression of PKR promotes network excitability and enhanced cognition by interferon-?-mediated disinhibition. Cell. 2011;147:1384-96 pubmed出版商 Hays S, Huber K, Gibson J. Altered neocortical rhythmic activity states in Fmr1 KO mice are due to enhanced mGluR5 signaling and involve changes in excitatory circuitry. J Neurosci. 2011;31:14223-34 pubmed出版商 Wei H, Masterson S, Petry H, Bickford M. Diffuse and specific tectopulvinar terminals in the tree shrew: synapses, synapsins, and synaptic potentials. PLoS ONE. 2011;6:e23781 pubmed出版商 Allen D, Nakayama S, Kuroiwa M, Nakano T, Palmateer J, Kosaka Y, et al. SK2 channels are neuroprotective for ischemia-induced neuronal cell death. J Cereb Blood Flow Metab. 2011;31:2302-12 pubmed出版商 Straub C, Hunt D, Yamasaki M, Kim K, Watanabe M, Castillo P, et al. Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1. Nat Neurosci. 2011;14:866-73 pubmed出版商 Allen D, Bond C, Lujan R, Ballesteros Merino C, Lin M, Wang K, et al. The SK2-long isoform directs synaptic localization and function of SK2-containing channels. Nat Neurosci. 2011;14:744-9 pubmed出版商 Errington A, Gibson K, Crunelli V, Cope D. Aberrant GABA(A) receptor-mediated inhibition in cortico-thalamic networks of succinic semialdehyde dehydrogenase deficient mice. PLoS ONE. 2011;6:e19021 pubmed出版商 Wu W, Adelman J, Maylie J. Ovarian hormone deficiency reduces intrinsic excitability and abolishes acute estrogen sensitivity in hippocampal CA1 pyramidal neurons. J Neurosci. 2011;31:2638-48 pubmed出版商 Zschenderlein C, Gebhardt C, Von Bohlen Und Halbach O, Kulisch C, Albrecht D. Capsaicin-induced changes in LTP in the lateral amygdala are mediated by TRPV1. PLoS ONE. 2011;6:e16116 pubmed出版商 Dilger E, Shin H, Guido W. Requirements for synaptically evoked plateau potentials in relay cells of the dorsal lateral geniculate nucleus of the mouse. J Physiol. 2011;589:919-37 pubmed出版商 Buchanan K, Petrovic M, Chamberlain S, Marrion N, Mellor J. Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels. Neuron. 2010;68:948-63 pubmed出版商 Lobb C, Wilson C, Paladini C. A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons. J Neurophysiol. 2010;104:403-13 pubmed出版商 Cea del Rio C, Lawrence J, Tricoire L, Erdelyi F, Szabo G, McBain C. M3 muscarinic acetylcholine receptor expression confers differential cholinergic modulation to neurochemically distinct hippocampal basket cell subtypes. J Neurosci. 2010;30:6011-24 pubmed出版商 Zhang G, Chen W, Lao L, Marvizon J. Cannabinoid CB1 receptor facilitation of substance P release in the rat spinal cord, measured as neurokinin 1 receptor internalization. Eur J Neurosci. 2010;31:225-37 pubmed出版商 Hoffman A, Laaris N, Kawamura M, Masino S, Lupica C. Control of cannabinoid CB1 receptor function on glutamate axon terminals by endogenous adenosine acting at A1 receptors. J Neurosci. 2010;30:545-55 pubmed出版商 Zhang W, Buckmaster P. Dysfunction of the dentate basket cell circuit in a rat model of temporal lobe epilepsy. J Neurosci. 2009;29:7846-56 pubmed出版商 Balakrishnan V, Kuo S, Roberts P, Trussell L. Slow glycinergic transmission mediated by transmitter pooling. Nat Neurosci. 2009;12:286-94 pubmed出版商 Hellier J, White A, Williams P, Dudek F, Staley K. NMDA receptor-mediated long-term alterations in epileptiform activity in experimental chronic epilepsy. Neuropharmacology. 2009;56:414-21 pubmed出版商 Atherton J, Wokosin D, Ramanathan S, Bevan M. Autonomous initiation and propagation of action potentials in neurons of the subthalamic nucleus. J Physiol. 2008;586:5679-700 pubmed出版商 Dargan S, Clarke V, Alushin G, Sherwood J, Nistic???? R, Bortolotto Z, et al. ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function. Neuropharmacology. 2009;56:121-30 pubmed出版商 Molineux M, Mehaffey W, Tadayonnejad R, Anderson D, Tennent A, Turner R. Ionic factors governing rebound burst phenotype in rat deep cerebellar neurons. J Neurophysiol. 2008;100:2684-701 pubmed出版商 Wu W, Chan C, Surmeier D, Disterhoft J. Coupling of L-type Ca2+ channels to KV7/KCNQ channels creates a novel, activity-dependent, homeostatic intrinsic plasticity. J Neurophysiol. 2008;100:1897-908 pubmed出版商 Shen W, Flajolet M, Greengard P, Surmeier D. Dichotomous dopaminergic control of striatal synaptic plasticity. Science. 2008;321:848-51 pubmed出版商 Jüngling K, Seidenbecher T, Sosulina L, Lesting J, Sangha S, Clark S, et al. Neuropeptide S-mediated control of fear expression and extinction: role of intercalated GABAergic neurons in the amygdala. Neuron. 2008;59:298-310 pubmed出版商 Power J, Sah P. Competition between calcium-activated K+ channels determines cholinergic action on firing properties of basolateral amygdala projection neurons. J Neurosci. 2008;28:3209-20 pubmed出版商 Maher B, Westbrook G. Co-transmission of dopamine and GABA in periglomerular cells. J Neurophysiol. 2008;99:1559-64 pubmed出版商 Darbin O, Wichmann T. Effects of striatal GABA A-receptor blockade on striatal and cortical activity in monkeys. J Neurophysiol. 2008;99:1294-305 pubmed出版商 McElligott Z, Winder D. Alpha1-adrenergic receptor-induced heterosynaptic long-term depression in the bed nucleus of the stria terminalis is disrupted in mouse models of affective disorders. Neuropsychopharmacology. 2008;33:2313-23 pubmed Chiu C, Castillo P. Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus. Neuropharmacology. 2008;54:68-78 pubmed Karson M, Whittington K, Alger B. Cholecystokinin inhibits endocannabinoid-sensitive hippocampal IPSPs and stimulates others. Neuropharmacology. 2008;54:117-28 pubmed Fukunaga I, Yeo C, Batchelor A. Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices. Br J Pharmacol. 2007;151:870-6 pubmed Bonislawski D, Schwarzbach E, Cohen A. Brain injury impairs dentate gyrus inhibitory efficacy. Neurobiol Dis. 2007;25:163-9 pubmed Takayasu Y, Iino M, Shimamoto K, Tanaka K, Ozawa S. Glial glutamate transporters maintain one-to-one relationship at the climbing fiber-Purkinje cell synapse by preventing glutamate spillover. J Neurosci. 2006;26:6563-72 pubmed Safo P, Regehr W. Endocannabinoids control the induction of cerebellar LTD. Neuron. 2005;48:647-59 pubmed Kinney G. GAT-3 transporters regulate inhibition in the neocortex. J Neurophysiol. 2005;94:4533-7 pubmed Sylantyev S, Lee C, Shyu B. A parametric assessment of GABA antagonist effects on paired-pulse facilitation in the rat anterior cingulate cortex. Neurosci Res. 2005;52:362-70 pubmed Ying S, Goldstein P. Propofol suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A) receptor chloride channels. Mol Pain. 2005;1:2 pubmed Haj Dahmane S, Shen R. The wake-promoting peptide orexin-B inhibits glutamatergic transmission to dorsal raphe nucleus serotonin neurons through retrograde endocannabinoid signaling. J Neurosci. 2005;25:896-905 pubmed Huang Y, Sinha S, Tanaka K, Rothstein J, Bergles D. Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. J Neurosci. 2004;24:4551-9 pubmed Wood M, Murkitt K, Rice S, Testa T, Punia P, Stammers M, et al. The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. Br J Pharmacol. 2000;131:1050-4 pubmed 图像 1: Cat.No. 1248 - CGP 55845 hydrochloride C18H22Cl2NO3P.HCl CAS No. 149184-22-5网址印刷: ?utm_source=labome utm_medium=referral utm_campaign=product utm_term=smallmolecules功能细节: Potent, selective GABAB receptor antagonist (IC50 = 5 nM) that prevents agonist binding (pKi = 8.35) and inhibits GABA and glutamate release (pEC50 values are 8.08 and 7.85 respectively). Inhibits GABAB responses to baclofen (IC50 = 130 nM in an isoproterenol assay) and potentiates the hypoglycemic response to glucose in vitro /em .catalog number base: extended description: Potent and selective GABAB antagonist化学品名文本: (2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl)phosphinic acid hydrochloride配方: C sub /sub sub /sub sub /sub sub /sub P.HCl配方文本: C18H22Cl2NO3P.氯化氢cas num: 149184-22-52020 Proposedprice USD: 214美元产品细节: Potent and selective GABAB antagonist储存: 存放在RT更多信息或购买: Tocris Bioscience 蚂蚁淘页Tocris BioscienceThe Watkins BuildingAtlantic RoadAvonmouth, BristolBS11 9QDinfo@bio-techne.comhttps://www.tocris.com800-343-7475公司总部: 英国

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