Description: Sustains self-renewal and pluripotency of ESCs Chemical Name: 1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol Purity: ≥99% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Sustains self-renewal and pluripotency of mouse embryonic stem cells (ESCs) in vitro. Stimulates proliferation at a steady rate (observed in serum-free media supplemented with 10 μM over a 30 day period).

Compound Libraries

ID 8 is also offered as part of the Tocriscreen Plus and Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	298.29
Formula	C16H14N2O4
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	147591-46-6
PubChem ID	791637
InChI Key	VVZNWYXIOADGSW-UHFFFAOYSA-N
Smiles	CC2=C([N+]([O-])=O)C1=CC=C(O)C=C1N2C3=CC=C(OC)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

DMSO	29.83	100

Preparing Stock Solutions

The following data is based on the product molecular weight 298.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	3.35 mL	16.76 mL	33.52 mL
5 mM	0.67 mL	3.35 mL	6.7 mL
10 mM	0.34 mL	1.68 mL	3.35 mL
50 mM	0.07 mL	0.34 mL	0.67 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Miyabayashi et al (2008) Indole derivatives sustain embryonic stem cell self-renewal in long-term culture. Biosci.Biotechnol.Biochem. 72 1242 PMID: 18460821

Firestone and Chen (2009) Controlling destiny through chemistry: small-molecule regulators of cell fate. ACS Chem.Biol. 5 15 PMID:

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Keywords: ID 8, supplier, Sustains, self-renewal, pluripotency, embryonic, stem, cells, ESCs, id8, id, 8, Stem, Cell, Proliferation, Stem, Cell, Proliferation, Tocris Bioscience

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