生物活性

Sulfated glycosaminoglycan (sGAG) mimetic that targets soluble amyloid (A ) and maintains A in a non-fibrillar form. Decreases A 42-induced neuronal death and inhibits amyloid deposition in vitro. Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Also a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo.

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以下数据基于产品分子量 139.17。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.Molarity Calculator Calculate the mass, volume, or concentration required for a solution.

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et al (1982)Homotaurine (3 aminopropanesulfonic acid; 3APS) protects from the convulsant and cytotoxic effect of systemically administered kainic acid.Neurology 32 241 PMID:7199633

Gervais et al (2007)Targeting soluble A peptide with tramiprosate for the treatment of brain amyloidosis.Neurobiol.Aging 28 537 PMID:16675063

Santa-Maria et al (2007) Tramiprosate, a drug of potential interest for the treatment of Alzheimer s disease, promotes an abnormal aggregation of tau. Mol.Neurodegen. 2

If you know of a relevant reference for Tramiprosate, please let us know.

关键词: Tramiprosate, Tramiprosate supplier, Sulfated, glycosaminoglycan, sGAG, Targets, soluble, Amyloid-beta, -Amyloid, beta-Amyloid, b-amyloid, decrease, amyloid, plaque, deposition, Precursor, Protein, APP, Secretase, beta, Peptides, GABAA, GABAC, GABAB, Receptors, analogue, amyloidb, amyloid , Homotaurine, Amyloid, Beta, Miscellaneous, GABA, 3619, Tocris Bioscience

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Cat. No. 6779 Highly potent active component of ADNP; prevents amyloid β aggregation; active in vivo

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