Description: Antiangiogenic Alternative Names: CRC 87-09, NSC 817373 Chemical Name: 2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol Purity: ≥99% Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Antitumor, antiangiogenic and antimetastatic agent, in vitro and in vivo. Inhibits tubulin polymerization.

Technical Data

M. Wt	316.35
Formula	C18H20O5
Storage	Desiccate at -20°C
Purity	≥99%
CAS Number	117048-59-6
PubChem ID	5351344
InChI Key	HVXBOLULGPECHP-WAYWQWQTSA-N
Smiles	OC1=CC(C=C/C2=CC(OC)=C(OC)C(OC)=C2)=CC=C1OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

DMSO	31.64	100
ethanol	31.64	100

Preparing Stock Solutions

The following data is based on the product molecular weight 316.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	3.16 mL	15.81 mL	31.61 mL
5 mM	0.63 mL	3.16 mL	6.32 mL
10 mM	0.32 mL	1.58 mL	3.16 mL
50 mM	0.06 mL	0.32 mL	0.63 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Dorr et al (1996) Antitumor activity of combretastatin-A4 phosphate, a natural product tubulin inhibitor. Invest.New Drugs 14 131 PMID: 8913833

Griggs et al (2001) Potent anti-metastatic activity of combretastatin-A4. Int.J.Oncol. 19 821 PMID: 11562761

Lin et al (2007) Combretastatin A4-induced differential cytotoxicity and reduced metastatic ability by inhibition of AKT function in human gastric cancer cells. J.Pharmacol.Exp.Ther. 323 365 PMID: 17646428

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Keywords: Combretastatin A4, supplier, inhibitors, inhibits, tubulin, polymerization, Antitumor, antimetastatic, Antiangiogenics, Tau, Microtubules, Mitosis, CombretastatinA4, CRC87-09, NSC817373, CRC, 87-09, NSC, 817373, Microtubules, Mitosis, Antiangiogenics, Antiangiogenics, Tocris Bioscience

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