Description: Selective negative allosteric modulator of mGlu₃ Chemical Name: (3S)-N-(2,4-Dichlorobenzyl)-1-(5-bromopyrimidin-2-yl)pyrrolidinyl-3-amine hydrochloride Purity: ≥98% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Selective negative allosteric modulator of mGlu₃ (IC₅₀ = 190 nM). Exhibits > 65-fold selectivity for mGlu₃ over other mGlu receptors. Abolishes the neuroprotective action of LY 379268 against amyloid β toxicity in mixed cortical neuronal and astrocyte cell cultures.

Technical Data

M. Wt	438.58
Formula	C15H15BrCl2N4.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	885104-09-6
PubChem ID	11503054
InChI Key	IRIBLLOEUZMCQY-ZOWNYOTGSA-N
Smiles	ClC1=CC(Cl)=CC=C1CN[C@@H]2CN(C3=NC=C(Br)C=N3)CC2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

DMSO	8.77	20

Preparing Stock Solutions

The following data is based on the product molecular weight 438.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	2.28 mL	11.4 mL	22.8 mL
5 mM	0.46 mL	2.28 mL	4.56 mL
10 mM	0.23 mL	1.14 mL	2.28 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Caraci et al (2011) Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer\'s disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mGl Mol.Pharmacol. 79 618 PMID: 21159998

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Keywords: LY 2389575 hydrochloride, supplier, LY2389575, hydrochloride, selective, negative, allosteric, modulators, NAM, group, II, 2, glutamate, receptors, mGlu3, Glutamate, (Metabotropic), Group, II, Receptors, Glutamate, (Metabotropic), Group, II, Receptors, Tocris Bioscience

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