Biological Activity
Inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Displays no effect on the transactivational or cell cycle checkpoint control function of p53. Potentially increases reprogramming efficiency of human somatic cells to induced pluripotent stem cells (iPSCs) by silencing p53. Reduces cell death induced by γ-radiation in vitro and protects mice from doses of radiation that cause lethal hematopoietic syndrome. Selectively inhibits heat shock protein 70 (HSP70) activity.
Compound Libraries
Pifithrin-μ is also offered as part of the Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 181.21 |
| Formula | C8H7NO2S |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 64984-31-2 |
| PubChem ID | 327653 |
| InChI Key | ZZUZYEMRHCMVTB-UHFFFAOYSA-N |
| Smiles | NS(=O)(=O)C#CC1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| DMSO | 13.12 | 100 |
| ethanol | 13.12 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 181.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 1 mM | 5.52 mL | 27.59 mL | 55.18 mL |
| 5 mM | 1.1 mL | 5.52 mL | 11.04 mL |
| 10 mM | 0.55 mL | 2.76 mL | 5.52 mL |
| 50 mM | 0.11 mL | 0.55 mL | 1.1 mL |
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Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDSReferences
References are publications that support the products\' biological activity.
Strom et al (2006) Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nat.Chem.Biol. 2 474 PMID: 16862141
Leu et al (2009) A small molecule inhibitor of inducible heat shock protein 70 (HSP70). Mol.Cell 36 15 PMID: 19818706
Kawamura et al (2009) Linking the p53 tumor suppressor pathway to somatic cell reprogramming. Nature 460 1140 PMID: 19668186
Steele et al (2009) 2-phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells. Blood 114 1217 PMID: 19515722
Keywords: Pifithrin-mu, supplier, inhibitors, inhibits, p53-mitochondrial, binding, Transcription, Factors, MDM2, p14ARF, Pifithrin-mu, NSC303580, NSC, 303580, p53, Reprogramming, Hsp70, p53, Tocris Bioscience
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