Description: Potent group I mGlu antagonist Chemical Name: N-Phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide Purity: ≥98% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Group I metabotropic glutamate receptor antagonist (IC₅₀ ~ 3 μM); 67 times more potent than (S)-4-carboxyphenylglycine (Cat. No. 0323). Also a positive allosteric modulator for mGlu_4a; potentiates L-AP4-mediated inhibition of striatopallidal synaptic transmission in vitro. Displays antiParkinsonian effects in rats in vivo.

Licensing Information

Sold for research purposes under license from Suntory Ltd.

Compound Libraries

PHCCC is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	294.31
Formula	C17H14N2O3
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	179068-02-1
PubChem ID	5866327
InChI Key	FPXPIEZPAXSELW-CYVLTUHYSA-N
Smiles	O=C(NC4=CC=CC=C4)C3(C2C3)OC1=CC=CC=C1/C2=N/O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

DMSO	29.43	100

Preparing Stock Solutions

The following data is based on the product molecular weight 294.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	3.4 mL	16.99 mL	33.98 mL
5 mM	0.68 mL	3.4 mL	6.8 mL
10 mM	0.34 mL	1.7 mL	3.4 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

Molarity Calculator

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution. Reconstitution Calculator

Reconstitution Calculator

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Mao and Wang (2001) Selective activation of group I metabotropic glutamate receptors upregulates preprodynorphin, substance P and preproenkephalin mRNA expression in rat dorsal striatum. Synapse 39 82 PMID: 11071713

Marino et al (2003) Allosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinson\'s disease treatment. Proc.Natl.Acad.Sci.USA 100 13668 PMID: 14593202

Annoura et al (1996) A novel class of antagonists for metabotropic glutamate receptors, 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylates. Bioorg.Med.Chem.Lett. 6 763 PMID:

Flor et al (2002) Positive allosteric modulators of metabotropic glutamate receptor subtype 4: pharmacological and molecular characterization. Neuropharmacology 43 286 Abstr.No. 47 PMID:

---

Keywords: PHCCC, supplier, Potent, group, I, mGlur, antagonists, Group, Receptors, mGlu1, mGlu5, Glutamate, Metabotropic, mGlu4, Glutamate, (Metabotropic), Group, I, Receptors, Glutamate, (Metabotropic), Group, I, Receptors, Tocris Bioscience

>>> 更多资讯详情请访问蚂蚁淘商城