Description: Positive allosteric modulator of group I mGlu receptors Chemical Name: (9H-Xanthen-9-ylcarbonyl)-carbamic acid butyl ester Purity: ≥99% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Positive allosteric modulator of mGlu group I receptors (pEC₅₀ value is 7.16 for the rat mGlu_1a receptor). Exhibits activity at all group I receptors, including human and rat mGlu₁ and rat mGlu₅. Enhances the effects of (S)-DHPG in CA3 neurons (EC₅₀ = 95 nM).

Technical Data

M. Wt	325.36
Formula	C19H19NO4
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	302841-89-0
PubChem ID	9949202
InChI Key	RQBUXEUMZZQUFY-UHFFFAOYSA-N
Smiles	O=C(NC(OCCCC)=O)C2C3=C(C=CC=C3)OC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

DMSO	32.54	100

Preparing Stock Solutions

The following data is based on the product molecular weight 325.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	3.07 mL	15.37 mL	30.74 mL
5 mM	0.61 mL	3.07 mL	6.15 mL
10 mM	0.31 mL	1.54 mL	3.07 mL
50 mM	0.06 mL	0.31 mL	0.61 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Knoflach et al (2001) Positive allosteric modulators of metabotropic glutamate receptor: Characterizationn, mechanism of action, and binding site. Proc.Natl.Acad.Sci. 98 13402 PMID: 11606768

Hempstapat et al (2006) A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Mol.Pharmacol. 70 616 PMID: 16645124

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Keywords: Ro 67-4853, supplier, Ro67-4853, PAM, positive, allosteric, modulator, modulators, metabotropic, glutamate, receptor, 1, enhancer, mGlu1, receptors, Glutamate, (Metabotropic), Group, I, Receptors, Glutamate, (Metabotropic), Group, I, Receptors, Tocris Bioscience

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