Description: Potent, selective H₂ antagonist Alternative Names: ICI 125,211 Purity: ≥99% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Potent histamine H₂-receptor antagonist with negligible activity against H₁- and H₃- receptors.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries

Tiotidine is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	312.41
Formula	C10H16N8S2
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	69014-14-8
PubChem ID	50287
InChI Key	YDDXVAXDYKBWDX-UHFFFAOYSA-N
Smiles	CNC(NCCSCC1=CSC(N=C(/N)N)=N1)=N/C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility

Soluble to 10 mM in ethanol and to 100 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 312.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	3.2 mL	16 mL	32.01 mL
5 mM	0.64 mL	3.2 mL	6.4 mL
10 mM	0.32 mL	1.6 mL	3.2 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

Molarity Calculator

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution. Reconstitution Calculator

Reconstitution Calculator

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Hill (1990) Distribution, properties, and functional characteristics of three classes of histamine receptor. Pharmacol.Rev. 42 45 PMID: 2164693

Trzeciakowski and Levi (1980) The cardiac pharmacology of tiotidine (ICI 125,211): A new histamine H₂- receptor antagonist. J.Pharmacol.Exp.Ther. 214 629 PMID: 6105207

Yellin et al (1979) ICI 125,211: A new gastric antisecretory agent acting on histamine H₂- receptors. Life Sci. 25 2001 PMID: 43449

---

Keywords: Tiotidine, supplier, Potent, selective, H2, antagonists, Receptors, Histamine, histaminergic, AstraZeneca, ICI125211, ICI, 125,211, Histamine, H2, Receptors, Histamine, H2, Receptors, Tocris Bioscience

>>> 更多资讯详情请访问蚂蚁淘商城