Description: Leukotriene receptor antagonist Chemical Name: 7-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy]-4-oxo-8-propyl-4H-1-benzopyran-2-carboxylic acid Purity: ≥97% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Leukotriene receptor antagonist; inhibits contraction of guinea pig trachealis induced by leukotrienes C₄, D₄, E₄ and F₄.

Technical Data

M. Wt	498.52
Formula	C27H30O9
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	40785-97-5
PubChem ID	105007
InChI Key	LMQBMWHHGVZWMR-UHFFFAOYSA-N
Smiles	CCCC1=C(O)C(=CC=C1OCC(O)COC1=CC=C2C(=O)C=C(OC2=C1CCC)C(O)=O)C(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

100mM NaOH	24.93	50

Preparing Stock Solutions

The following data is based on the product molecular weight 498.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	2.01 mL	10.03 mL	20.06 mL
5 mM	0.4 mL	2.01 mL	4.01 mL
10 mM	0.2 mL	1 mL	2.01 mL
50 mM	0.04 mL	0.2 mL	0.4 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Jones et al (1983) Pharmacological study of the effects of leukotrienes C4, D4, E4 & F4 on guinea pig trachealis: interaction with FPL-55712. Prostaglandins 26 833 PMID: 6322240

O\'Donnell and Welto (1984) Pharmacologic properties of FPL 55712 administered by aerosol. Agents Actions 14 43 PMID: 6322547

Folkerts et al (1995) Leukotrienes mediate tracheal hyperresponsiveness after nitric oxide synthesis inhibition. Eur.J.Pharmacol. 285 R1 PMID: 8566126

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Keywords: FPL 55712, supplier, leukotrienes, eicosanoids, receptor, antagonists, CysLT1, Receptors, receptors, LTD4, LTE4, FPL55712, Leukotriene, and, Related, Receptors, Leukotriene, and, Related, Receptors, Tocris Bioscience

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