Description: Highly selective A₃ agonist Chemical Name: 1-[2-Chloro-6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-1-deoxy-N-methyl-β-D-ribofuranuronamide Purity: ≥98% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

High affinity and extremely selective A₃ adenosine receptor agonist (K_i = 0.33 nM). Displays 2500- and 1400-fold selectivity over A₁ and A_2A receptors respectively. Exhibits high selectivity over the Na⁺-independent adenosine transporter.

Licensing Information

Sold with the permission of the NIH, US Patent 08/091,109

Technical Data

M. Wt	544.74
Formula	C18H18ClIN6O4
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	163042-96-4
PubChem ID	3035850
InChI Key	IPSYPUKKXMNCNQ-PFHKOEEOSA-N
Smiles	O[C@@H]1[C@@H]([C@](NC)=O)O[C@@H](N(C=N4)C2=C4C(NCC3=CC(I)=CC=C3)=NC(Cl)=N2)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility

Soluble to 100 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 544.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	1.84 mL	9.18 mL	18.36 mL
5 mM	0.37 mL	1.84 mL	3.67 mL
10 mM	0.18 mL	0.92 mL	1.84 mL
50 mM	0.04 mL	0.18 mL	0.37 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Jacobson (1998) Adenosine A₃ receptors: novel ligands and paradoxical effects. TiPS 19 184 PMID: 9652191

Kim et al (1994) 2-Substitution of N⁶-benzyladenosine-5\'-uronamides enhances selectivity for A₃ adenosine receptors. J.Med.Chem. 37 3614 PMID: 7932588

Schaick et al (1996) Hemodynamic effects of histamine release elicited by the selective adenosine A₃ receptor agonist 2-Cl-IB-MECA in conscious rats. Eur.J.Pharmacol. 308 311 PMID: 8858305

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Keywords: 2-Cl-IB-MECA, supplier, selective, A3, agonists, Receptors, adenosines, 2ClIBMECA, Adenosine, A3, Receptors, Adenosine, A3, Receptors, Tocris Bioscience

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