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蚂蚁淘在线 / 品牌中心 / Tocris / Tocris/Pladienolide B/6070/500U/500 ug

Tocris/Pladienolide B/6070/500U/500 ug

价格
￥6580.00
货号：6070/500U
浏览量：127
品牌：Tocris
服务
全国联保
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正规发票
签订合同
商品描述
Description:mRNAsplicinginhibitor;antitumor
ChemicalName:(4R,7R,8S,9E,11S,12S)-8-(Acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-hexADIen-1-yl]-7,11-dimethyloxacyclododec-9-en-2-one
Purity:≥95%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

mRNAsplicinginhibitor;decreasessplicingcapacityupto75%invitro.Directlytargetssplicesome-associated130(SAP130),inhibitssplicingfactor3Bsubunit(SF3B1)andimpairsU2smallnuclearribonucleoprotein(U2snRNP)interactionwithpre-mRNA.ArrestscellcycleinG1andG2/Mphases.Displaysantitumoractivityagainstgastriccancercells(IC50valuesare1.6-4.9nM).Cellpermeableandactiveinvivo.

TechnicalData

M.Wt536.7
FormulaC30H48O8
StorageStoreat-20°C
Purity≥95%(HPLC)
CASNumber445493-23-2
PubChemID90909513
InChIKeySDOUORKJIJYJNW-UHFFFAOYSA-N
SmilesC[C@@H](/C=C/[C@H](OC(C)=O)[C@](C)(O)CC[C@@H](O)C1)[C@@H](/C(C)=C/C=C/[C@@H](C)C[C@@H]2[C@@H]([C@H](C)[C@@H](O)CC)O2)OC1=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO12

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight536.7.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.86mL9.32mL18.63mL
5mM0.37mL1.86mL3.73mL
10mM0.19mL0.93mL1.86mL
50mM0.04mL0.19mL0.37mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet