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蚂蚁淘在线 / 品牌中心 / Tocris / Tocris/BAY 41-8543/5708/10/10 mg

Tocris/BAY 41-8543/5708/10/10 mg

价格
￥4100.00
货号：5708/10
浏览量：127
品牌：Tocris
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商品描述
Description:Guanylylcyclase(sGC)stimulator
ChemicalName:2-[1-[(2-Fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-4,6-pyrimidinediamine
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Guanylylcyclase(sGC)stimulator.IncreasesactivityofsGCbyupto92-foldatconcentrationsupto100μM.Inducesrelaxationofaorta,saphenousarteries,coronaryarteriesandveinsinvitro.Inhibitscollagen-inducedplateletaggregation.PromoteslipiduptakeintobrownADIposetissueandincreasesenergyexpenditureinmice.Inducesweightlossinobesemice.Antihypertensive.

TechnicalData

M.Wt420.44
FormulaC21H21FN8O
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber256498-66-5
PubChemID9953906
InChIKeyAQYFUZRYBJBAGZ-UHFFFAOYSA-N
SmilesFC1=CC=CC=C1CN2N=C(C3=NC(N)=C(N4CCOCC4)C(N)=N3)C5=CC=CN=C52

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO4.210mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight420.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.38mL11.89mL23.78mL
5mM0.48mL2.38mL4.76mL
10mM0.24mL1.19mL2.38mL
50mM0.05mL0.24mL0.48mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet