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商品描述
Stauprimideisasemi-syntheticanalogueofthestaurosporinefamilyofindolocarbazoles.Stauprimidewasfirstpublishedin1994aspartofanextensivestructure-activityinvestigationtoimprovetheselectiveinhibitionofproteinkinaseCasapotentialantitumoragent.Morerecently,stauprimidehasbeenshowntoincreasetheefficiencyofthedirecteddifferentiationofmouseandhumanembryonicstemcellsinsynergywithdefinedextracellularsignallingcues.StauprimideinteractswithNME2(PUF)transcriptionfactortodown-regulatec-Mycexpression,leADIngtodifferentiationofstemcells.
AdditionalInformation
| Synonyms | N-Benzoyl-7-oxostaurosporine |
|---|---|
| Product# | S-2092 |
| CAS# | 154589-96-5 |
| ChemicalName | N-((5S,6R,7R,9R)-6-METHOXY-5-METHYL-14,16-DIOXO-5,6,7,8,9,14,15,16-OCTAHYDRO-17-OXA-4B,9A,15-TRIAZA-5,9-METHANODIBENZO[B,H]CYCLONONA[JKL]CYCLOPENTA[E]-AS-INDACEN-7-YL)-N-METHYLBENZAMIDE |
| Formula | C35H28N4O5 |
| MW | 584.6 |
| Appearance | YellowOrangeSolid |
| Purity | 98%byTLC |
| Solubility | Solubleinmethanol,ethanol,DMForDMSO |
| BoilingPoint | 145°C |
| StorageTemp | -20°C |
| TherapeuticArea | OncologicalDisorders |
| Use | StauprimideinhibitsthenuclearlocalizationofNME2,blockinganddownregulatingc-Mycexpressionincertaincancers |
| MDLNumber | MFCD14635443 |
|---|---|
| ChemACX | X1763223-8 |
| InChI | InChI=1S/C35H28N4O5/c1-35-31(43-3)23(37(2)34(42)18-11-5-4-6-12-18)17-24(44-35)38-21-15-9-7-13-19(21)25-27-28(33(41)36-32(27)40)26-20-14-8-10-16-22(20)39(35)30(26)29(25)38/h4-16,23-24,31H,17H2,1-3H3,(H,36,40,41)/t23-,24-,31-,35+/m1/s1 |
| SMILES | C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(=O)NC6=O)N(C)C(=O)C9=CC=CC=C9)OC |
