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4000-520-616 / 18915418616
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0512-67156496
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商品描述
PRAS40 (phospho-Ser183) rabbit pAb
- Catalog No.：YP1449
- Applications：WB
- Reactivity：Human,Mouse
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- Gene Name：
- AKT1S1 PRAS40
- Protein Name：
- PRAS40 (Ser183)
- Human Gene Id：
- 84335
- Human Swiss Prot No：
- Q96B36
- Mouse Gene Id：
- 67605
- Mouse Swiss Prot No：
- Q9D1F4
- Immunogen：
- Synthesized phosho peptide around human PRAS40 (Ser183)
- Specificity：
- This antibody detects endogenous levels ofHuman Mouse PRAS40 (phospho-Ser183)
- Formulation：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source：
- Rabbit
- Dilution：
- WB 1:1000-2000
- Purification：
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- Concentration：
- 1 mg/ml
- Storage Stability：
- -20°C/1 year
- Other Name：
- Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate)
- Observed Band(KD)：
- 40
- Background：
- AKT1 substrate 1(AKT1S1)Homo sapiensAKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM, Mar 2008],
- Function：
- function:May play an important role in phosphatidylinositol 3-kinase (PI3K)-AKT1 survival signaling. Substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. Its role in survival signaling pathways may be modulated by oxidative stress. May also play a role in nerve growth factor-mediated neuroprotection.,subcellular location:Found in the cytosolic fraction of the brain.,subunit:The phosphorylated form interacts with 14-3-3.,tissue specificity:Widely expressed with highest levels of expression in liver and heart. Expressed at higher levels in cancer cell lines (e.g. A549 and HeLa) than in normal cell lines (e.g. HEK293).,
- Subcellular Location：
- nucleoplasm,cytoplasm,cytosol,TORC1 complex,protein complex,
- Expression：
- Brain,Epithelium,Eye,Skin,
- June 19-2018
- WESTERN IMMUNOBLOTTING PROTOCOL
- June 19-2018
- IMMUNOHISTOCHEMISTRY-PARAFFIN PROTOCOL
- June 19-2018
- IMMUNOFLUORESCENCE PROTOCOL
- June 19-2018
- FLOW CYTOMEYRT PROTOCOL
- July 13-2018
- CELL-BASED-ELISA-PROTOCOL-FOR-ACETYL-PROTEIN
- July 13-2018
- CELL-BASED-ELISA-PROTOCOL-FOR-PHOSPHO-PROTEIN
- July 13-2018
- CELL-BASED-COLORIMETRIC-ELISA-PROTOCOL-FOR-TOTAL-PROTEIN
- July 13-2018
- Antibody-FAQs
