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蚂蚁淘在线 / 品牌中心 / Immunoway / Immunoway/Progesterone Receptor (phospho-Ser345) rabbit pAb/20ug 50ug 100ug/YP1452
商品描述
Progesterone Receptor (phospho-Ser345) rabbit pAb
- Catalog No.：YP1452
- Applications：WB
- Reactivity：Human
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- Gene Name：
- PGR NR3C3
- Protein Name：
- Progesterone Receptor (Ser345)
- Human Gene Id：
- 5241
- Human Swiss Prot No：
- P06401
- Mouse Swiss Prot No：
- Q00175
- Rat Gene Id：
- 25154
- Rat Swiss Prot No：
- Q63449
- Immunogen：
- Synthesized phosho peptide around human Progesterone Receptor (Ser345)
- Specificity：
- This antibody detects endogenous levels ofHuman Progesterone Receptor (phospho-Ser345)
- Formulation：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source：
- Rabbit
- Dilution：
- WB 1:1000-2000
- Purification：
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- Concentration：
- 1 mg/ml
- Storage Stability：
- -20°C/1 year
- Other Name：
- Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3)
- Observed Band(KD)：
- 105
- Background：
- progesterone receptor(PGR)Homo sapiensThis gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015],
- Function：
- domain:Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.,function:Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.,function:The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.,online information:Progesterone receptor entry,PTM:Phosphorylated on multiple serine sites. Several of these sites are hormone-dependent. Phosphorylation on Ser-294 occurs preferentially on isoform B, is highly hormone-dependent and modulates ubiquitination and sumoylation on Lys-388. Phosphorylation on Ser-102 and Ser-345 also requires induction by hormone. Basal phosphorylation on Se
- Subcellular Location：
- nucleus,nucleoplasm,mitochondrial outer membrane,
- Expression：
- Breast cancer,Platelet,Sperm,
- June 19-2018
- WESTERN IMMUNOBLOTTING PROTOCOL
- June 19-2018
- IMMUNOHISTOCHEMISTRY-PARAFFIN PROTOCOL
- June 19-2018
- IMMUNOFLUORESCENCE PROTOCOL
- June 19-2018
- FLOW CYTOMEYRT PROTOCOL
- July 13-2018
- CELL-BASED-ELISA-PROTOCOL-FOR-ACETYL-PROTEIN
- July 13-2018
- CELL-BASED-ELISA-PROTOCOL-FOR-PHOSPHO-PROTEIN
- July 13-2018
- CELL-BASED-COLORIMETRIC-ELISA-PROTOCOL-FOR-TOTAL-PROTEIN
- July 13-2018
- Antibody-FAQs
