Predicted Species Reactivity:Human, MouseProduct Format:LiquidClonality:PolyclonalIsotype:Rabbit IgGHost:RabbitApplication:WBAdditional Information:Function: Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium. Reconstitution and Storage:Store at 2-8C for up to 6 months. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.Gene Symbol:EPHA4Official Gene Full Name:EPH receptor A4NCBI Gene Id:2043Swissprot Id:P54764Protein Accession #:NP_001291465.1Nucleotide Accession #:NM_001304536.1Alias Symbols:SEK, HEK8, TYRO1Replacement Item:This antibody may replace item sc-120067 from Santa Cruz Biotechnology.Description of Target:This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Multiple transcript variants encoding different isoforms have been found for this gene.Molecular Weight:110 kDaTissue Tool:Find tissues and cell lines supported by DNA array analysis to express EPHA4. 
RNA Seq:Find tissues and cell lines supported by RNA-seq analysis to express EPHA4. 
Predicted Homology Based on Immunogen Sequence:Human, MouseDatasheets/Manuals:Printable datasheet for anti-EPHA4 (OAAB20270) antibodyPreservative:0.02% Sodium Azide and 50% glycerolTarget Post-Translational Modification:Phospho-Tyr596 我们在Aviva Systems Biology生产并提供含有重组蛋白或天然蛋白的裂解物，这些蛋白可在Western blot检测中用作阳性对照。重组蛋白在细菌，哺乳动物细胞和昆虫细胞中表达，并作为整体裂解物提供。
