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商品描述
Description:TLR2,Mouse,mAbmT2.4
MonoclonalantibodymT2.4reactswithmouseToll-likereceptor2(TLR2,CD282).Toll-likereceptors(TLR)arehighlyconservedthroughoutevolutionandhavebeenimplicatedintheinnatedefensetomanypathogens.InDrosophilatollisrequiredfortheanti-fungalresponse,whiletherelated18-wheelerisinvolvedinantibacterialdefenses.Inmammals,TLRidentifiedastypeItransmembranesignalingreceptorswithpatternrecognitioncapABIlities,havebeenimplicatedintheinnatehostdefensetopathogens.TLR2hasbeenidentifiedasareceptorthatiscentraltotheinnateimmuneresponsetolipoproteinsofGram-negativebacteria,severalwholeGram-positivebacteria,aswellasareceptorforpeptidoglycanandlipoteichoicacidandotherbacterialcellmembraneproducts.AfunctionalinteractionbetweenTLR2andTLR6inthecellularresponsetovariousbacterialproductshasbeendiscovered.ThecurrentlyacceptedparADIgmregardsTLR2asanessentialreceptorformanyeubacterialcellwallcomponents,includinglipoproteinsandpeptidoglycan.Bacterialspeciesasdiverseasmycobacteria,spiRochetes,mycoplasma,Staphylococcusaureus,andStreptococcuspneumoniaehaveallbeenshowntomediatecellularactivationviaTLR2.ThemonoclonalantibodymT2.4inhibitsmurineTLR2-mediatedcellactivation.ItmasksthelipopeptidebindingsiteintherecombinantextracellulardomainofTLR2(TLR2ECD)anddoesnothinderthereceptorcomplexformation.TheantibodyreactswiththenativeTLR2proteinandnotwithdenaturedTLR2protein.FurThermoretheantibodystainsoverexpressed,aswellasendogenouscellsurface-andintracellularmouseTLR2.
Specifications:
Catalognumber | HM1092 |
---|---|
Producttype | Monoclonalantibodies |
Quantity | 100µg |
Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbumin. |
Application | Flowcytometry,Frozensections,Functionalstudies,Immunoassays,Paraffinsections |
Use | Forimmunohistologyandflowcytometrydilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.ForneutralizationofBIOLOGicalactivityinvitrodilutionshavetobemadeaccordingtotheamountsofTLR2(CD282)tobeinactivated. |
Isotype | MouseIgG2b |
Species | Mouse |
References | Meng,Getal;MurineTLR2expressionanalysisandsystemicantagonismbyusageofspecificmonoclonalantibodies.ImmunologyLetters2005,98:200 |
Storageandstability | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
Disease | Infectiousdiseases |