品牌咨询
联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
Description:MHCclassI,Mouse,mAbER-MP42
ThemonoclonalantibodyER-MP42specificallyreactswithmajorhistocompatibilitycomplex(MHC)classIantigensofthemouseand,therefore,itisavaluabletoolforstudyingcytotoxicT-cellinteractionswithclassIpositiveantigenpresentingcells.TheprimaryimmunologicalfunctionofMHCmoleculesistobindandpresentantigenicpeptidesonthesurfacesofcellsforrecognitionbytheantigen-specificTcellreceptors(TCRs)oflymphocytes.MHCclassImoleculesareexpressedonthesurfacesofmostcellsandarerecognizedbyCD8-positivecytotoxicT-cells,anessentialstepforinitiatingtheeliminationofvirallyinfectedcellsbyT-cell-mediatedlysis.MHCclassImoleculesareheterodimerscomposedofanalpha(44kD)andabeta(betamicroglobulin,11kD)subunit.Thefirsttwostructuraldomainsofthealphasubunitassociatetoformthepeptide-bindingpocket.ThemonoclonalantibodyER-MP42reactswithMHCclassI,anantigenthatisexpressedbyallsomaticcellsatvaryinglevels.Lymphocytesarehighlypositive,whereasfibroblastsandneuronsshowonlyalowlevelofantigenexpression.ER-MP42recognizesmurineMHCclassImoleculesonthesurfaceofcellsofthefollowinghaplotypes:H-2Fv,H-2Dd,H-2k,q,s.Weakerreactivityisfoundinmiceofthefollowinghaplotypes:H-2p,r,w7,w22.MHCclassImoleculesofotherhaplotypesarenotrecognizedbyER-MP42.Thereisnocross-reactivitywithhumanMHCclassImolecules.
Specifications:
| Catalognumber | HM1091 |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 100µg |
| Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbuminand0.02%sodiumazide. |
| Application | Flowcytometry,Frozensections |
| Use | Forimmunohistologyandflowcytometry,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
| Isotype | RatIgG2a |
| Species | Mouse |
| StorageandstABIlity | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
| Disease | Infectiousdiseases |
