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商品描述
Description:MHCclassII,Mouse,mAbER-TR3
ThemonoclonalantibodyER-TR3reactswithmousemajorhistocompatibititycomplexclassII(MHCclassII),alsoknownasI-AorI-E.MHCclassIImoleculesareheterodimersofnon-covalentlyassociatedalpha(31-34kDa)andbeta(26-29kDa)chains.MajorhistocompatibilitycomplexclassIIantigenpresentationrequirestheparticipationoflysosomalproteasesintwoconvergentprocesses.First,theantigensendocytosedbytheantigen-presentingcellsmustbebrokendownintoantigenicpeptides.Second,classIImoleculesaresynthesizedwiththeirpeptide-bindingsiteblockedbyinvariantchain(Ii),andtheyacquirethecapacitytobindantigensonlyafterIihasbeendegradedinthecompartmentswherepeptidesreside.MHCclassIImoleculespresentexogenouslyderivedantigentoCD4+Tlymphocytes,whichareusuallyThelpercells.CD4interactswithnon-polymorphicresiduesofMHCClassII.ThemonoclonalantibodyER-TR3isavaluabletoolforstudyingThelpercellinteractionwithclassIIpositiveantigenpresentingcells(dendriticcells,Bcellsandmacrophages)andforstudyingthedevelopmentofThelpercellssincetheystainstromalcellsinthymus.ThelevelofantigendetectedbyER-TR3differsfromstraintostrain.ThemonoclonalantibodyER-TR3crossreactswithhumanMHCclassIIontonsil.DistributionofER-TR3amongmousestrainswithindependentandrecombinanthaplotypes.
Specifications:
Catalognumber | HM1087 |
---|---|
Producttype | Monoclonalantibodies |
Quantity | 100µg |
Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbuminand0.02%sodiumazide. |
Application | Flowcytometry,Frozensections |
Use | Forimmunohistologyandflowcytometrydilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
Isotype | RatIgG2b |
Species | Mouse |
References | 1.VanVliet,Eetal;Monoclonalantibodiestostromalcelltypesofthemousethymus.EurJImmunol1984,14:524 2.VanVliet,Eetal;Stromalcelltypesinthedevelopingthymusofthenormalandnudemouseembryo.EurJImmunol1985,15:675 |
StorageandstABIlity | Productshouldbestoredat4°C.Underrecommendedstorageconditions,productisstableforoneyear. |
Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
Disease | Infectiousdiseases |