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商品描述
Description:MARCO,Mouse,mAbED31
ThemonoclonalantibodyED31recognizesthemacrophagereceptorwithcollagenousstructure(MARCO).Thescavengerreceptors(SRs)expressedbymacrophagesarethoughttoplayanimportantroleintheimmuneresponseagainstbacteriabymediatingbindingandphagocytosis.AnimportantfamilyofreceptorsinvolvedintheseprocessesaretheclassAmacrophagescavengerreceptors(SR-A).TherearethreeclassesofSRs,A,BandC.SR-A,typeIandtypeII,arehomotrimericglycoproteinscomposedofthree77kDmonomers.MARCOisamemberofthisclassofscavengerreceptors.ThemolecularstructureofMARCOresemblesthatofSR-AI,containingatriple-helicalcollagenousdomainandascavengerreceptorcysteine-rich(SRCR)domainattheCterminus.MARCOisexpressedbydistinctpopulationsofmacrophagesinthespleenandlymphnodes.Itisrapidlyinducedonmacrophagesinothertissues(e.g.LiverKupfercells)duringinfectionorLPStreatment.MARCOseemstoplayanimportantroleinthelungsresponsetoinhaledparticlesandairbornepathogens.ThemonoclonalantibodyED31bindstotheC-terminalcysteinerichdomainofMARCO,andhasbeenshowntoblockligandbinding.
Specifications:
Catalognumber | HM1068 |
---|---|
Producttype | Monoclonalantibodies |
Quantity | 100µg |
Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containingand0.1%bovineserumalbumin. |
Application | Flowcytometry,Frozensections,Functionalstudies,Immunoprecipitation |
Use | Forimmunohistologyandflowcytometrydilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.ForneutralizationofBIOLOGicalactivityinvitrodilutionshavetobemadeaccordingtotheamountsofMARCOtobeinactivated. |
Isotype | RatIgG1 |
Species | Mouse |
References | 1.Laanvander,Letal;RegulationandfunctionalinvolvementofmacrophagescavengerreceptorMARCOinclearanceofbacteriainvivo.JImmunol1999,162:939 2.Palecanda,Aetal;RoleofthescavengerreceptorMARCOinalveolarmacrophagebindingofunopsonizedenviromentalparticles.JExpMed1999,189:1497 3.Arredouani,Metal;MARCOisthemajorbindingreceptorforunopsonizedparticlesandbacteriaonhumanalveolarmacrophages.JImmunol2005,175:6058 |
StorageandstABIlity | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
Disease | Infectiousdiseases |