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4000-520-616 / 18915418616
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0512-67156496
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商品描述
OVERVIEW:
Synonyms | Monoclonal ALOX15 antibody, Anti-ALOX15 antibody, 15-LOX-1 antibody, 15LOX-1 antibody, ALOX15, ALOX 15, ALOX-15, ALOX 15 antibody, ALOX-15 antibody |
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Cross Reactivity | Human |
Applications | FC, IF, IHC, WB |
Immunogen | ALOX15 antibody was raised in Mouse using full length human recombinant protein of human ALOX15 produced in HEK293T cell as the immunogen. |
SPECIFICATIONS:
Host | Mouse |
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Clone | 8C5 |
Isotype | IgG2a |
Method of Purification | ALOX15 antibody was purified by affinity chromatography. |
Form & Buffer | Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 0.5-1 mg/ml |
STORAGE & SAFETY:
Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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Usage Assay Information:
Usage Recommendations | WB: 1:500 |
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GENERAL INFORMATION:
Biological Significance | Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX, 15-LOX-1 and 15-LOX-2, which catalyze the regio-selective addition of oxygen into arachidonic acid, and epidermal LOX (E-LOX) which metabolizes 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE) to a specific epoxyalcohol compound. Different isozymes have different physiological roles; 5-, 12R-, 12S- and 15-LOX-1 have proliferative, antiapoptotic and angiogenic functions whilst 15-LOX-2 has roles in differentiation, growth arrest and the induction of apoptosis. E-LOX, the most divergent member of this family, is involved in terminal differentiation of keratinocytes and has a major role in skin barrier function. |
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