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蚂蚁淘在线 / 品牌中心 / Tocris / Tocris/ZM 323881 hydrochloride/2475/1/1 mg

Tocris/ZM 323881 hydrochloride/2475/1/1 mg

价格
￥2300.00
货号：2475/1
浏览量：127
品牌：Tocris
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商品描述
Description:Potent,selectiveinhibitorofVEGFR-2
ChemicalName:5-((7-Benzyloxyquinazolin-4-yl)amino)-4-fluoro-2-methylphenolhydrochloride
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentandselectiveinhibitorofhumanvascularendothelialgrowthfactorreceptor2(VEGFR-2/KDR)activity.SelectivelyinhibitsVEGFR-2(IC50=2nM)overVEGFR-1andarangeofotherreceptortyrosinekinasessuchasPDGFRβ,FGFR1,EGFRanderbB2(IC50>50μM).InhibitsVEGF-A-inducedendothelialcellproliferationinvitro(IC50=8nM).

LicensingInformation

SoldwiththepermissionofAstraZenecaUKLtd.

CompoundLibraries

ZM323881hydrochlorideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt411.86
FormulaC22H18FN3O2.HCl
StorageDesiccateat+4°C
Purity≥99%(HPLC)
CASNumber193000-39-4
PubChemID22624897
InChIKeyAVRHWGLIYGJSOD-UHFFFAOYSA-N
SmilesCl.CC1=C(O)C=C(NC2=C3C=CC(OCC4=CC=CC=C4)=CC3=NC=N2)C(F)=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO20.5950

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight411.86.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.43mL12.14mL24.28mL
5mM0.49mL2.43mL4.86mL
10mM0.24mL1.21mL2.43mL
50mM0.05mL0.24mL0.49mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet