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蚂蚁淘在线 / 品牌中心 / Tocris / Tocris/AZ 6102/5775/10/10 mg

Tocris/AZ 6102/5775/10/10 mg

价格
￥3980.00
货号：5775/10
浏览量：127
品牌：Tocris
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商品描述
Description:PotentTNKS1/2inhibitor
ChemicalName:rel-2-[4-[6-[(3R,5S)-3,5-Dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-4H-pyrrolo[2,3-d]pyrimidin-4-one
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentTNKS2andTNKS1inhibitor(IC50valuesare1and3nM,respectively).Exhibits>100-foldselectivityforTNKS1/2overPARP-1,PARP-2andPARP-6.InhibitsWntsignalinginDLD-1cells(IC50=5nM).ExhibitsmoderateoralbioavailABIlity.

ExternalPortalInformation

Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofAZ6102isreviewedonthechemicalprobeswebsite.

CompoundLibraries

AZ6102isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt428.53
FormulaC25H28N6O
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber1645286-75-4
PubChemID91663328
InChIKeyWCPTUQOMNJBIET-CALCHBBNSA-N
SmilesCC1=CC(N2C[C@H](C)N[C@H](C)C2)=NC=C1C3=CC=C(C(N4)=NC5=C(C=CN5C)C4=O)C=C3

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO21.4350

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight428.53.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.33mL11.67mL23.34mL
5mM0.47mL2.33mL4.67mL
10mM0.23mL1.17mL2.33mL
50mM0.05mL0.23mL0.47mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet