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蚂蚁淘在线 / 品牌中心 / Tocris / Tocris/ME 0328/5054/50/50 mg

Tocris/ME 0328/5054/50/50 mg

价格
￥15300.00
货号：5054/50
浏览量：127
品牌：Tocris
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商品描述
Description:SelectivePARP-3inhibitor
ChemicalName:3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

InhibitorofPARP-3(IC50=0.89μM).DisplaysselectivityforPARP-3overPARP-1,PARP-2andotherARDTenzymes(IC50valuesare6.3,10.8and>30μMrespectively).EnhancesCRISPR-Cas9-mediatedHER2mutationfrequency,resultinginincreasedreductioninproliferationofHER2-positivebreastcancercells.Cellpermeable.

CompoundLibraries

ME0328isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt321.37
FormulaC19H19N3O2
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber1445251-22-8
PubChemID71571526
InChIKeyQIHBWVVVRYYYRO-ZDUSSCGKSA-N
SmilesO=C2NC(CCC(N[C@@H](C)C3=CC=CC=C3)=O)=NC1=CC=CC=C12

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO32.14100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight321.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.11mL15.56mL31.12mL
5mM0.62mL3.11mL6.22mL
10mM0.31mL1.56mL3.11mL
50mM0.06mL0.31mL0.62mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet